Table 1.
NTRs, NLS and NES involved in transport of STAT proteins.
| STAT1 | STAT3 | STAT5A | STAT5B | |
|---|---|---|---|---|
| Importin | α5 [60,68], α7 [69] | α1 [70], α3 [70,71,72], α5 [69,70,72], α6 [71], α7 [69,72] | α3 [73] | n.d. 1 |
| Putative 2 NLS | L407-K413 [64,68] NTD involved [63,74] |
D150-K163 [71] R214/R215 [69] NTD involved [75] |
L142-E149 [76] intact CCD required [73] |
n.d. |
| Exportin | Crm1 [66] | Crm1 [75] | Crm1 (not exclusively) [73] | Crm1 (not exclusively) [77] |
| Putative 2 NES | W302-Q314 [78] M392-K413 [66] |
E306-K318 L404-R414 Q524-P535 [79] |
L119/L133 M403-Q474 [73] |
n.d. |
1 n.d., not determined; 2 in this context, “putative” means that the corresponding sequences do not fulfill classical NLS or NES functions but are required for nuclear transport or interaction with NTRs.