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. 2019 Oct 25;11(11):1654. doi: 10.3390/cancers11111654

Figure 3.

Figure 3

The combination triggers the DDR pathway and induces DNA damages independently for p53 functionality. (A) Western Blot analyses of RPMI-8402 and NALM-6 cell lines treated for 24 h with AZD-1775 (185 nM) and PF-00477736 (25 and 250 nM respectively). β-actin was used for loading normalization. For relative quantification of each protein see Figure S2 and for whole western blot images see Figure S5. (B) Western Blot analyses of RPMI-8402 and NALM-6 cell lines treated for 24 h with AZD-1775 (185 nM) and PF-00477736 (25 and 250 nM respectively). β-actin was used for loading normalization. For relative quantification of each protein see Figure S3A and for whole western blot images see Figure S6.