Figure 1.

Isoform-specific impact of histone variant macroH2A1 on the expression level of circadian lipogenic genes involved in non-alcoholic fatty liver disease pathogenesis. (A) Heat-map rendering mRNA expression levels of 24-h oscillating genes upon free fatty acid challenge in Hepa 1-6 cells stably over-expressing histone variant macroH2A1.1 and macroH2A1.2 isoforms; (B) STRING interaction network wiring the 24-h oscillating genes rendered in the heat-map. Edges are colored according to the nature of the interactions between genes. Cyan and magenta links correspond to known interactions from curated databases and experimentally determined findings; green, red, and blue links correspond to predicted interactions by gene neighborhood, gene fusion, and gene co-occurrence, respectively; light green, black, and light blue links represent text mining, co-expression, and protein homology evidence of interaction, respectively. Original data from [22,75].