Figure 3.

Comparison of biological relevance and topological properties of disease modules detected using three methods. (a) Bar graphs representing the number of the GO terms enriched in the added genes overlapped with the seed genes for DIAMOnD, SCA, and DIMSUM for the eight disease modules. The three GO term categories are Cellular Component (CC), Molecular Function (MF), and Biological Process (BP). The average of significant and identical GO terms from DIMSUM is higher than from DIAMOnD or SCA. (b) Degree distribution of the added genes during module detection for the eight diseases by each method. When building a module, DIMSUM avoids bias towards always including the nodes of high degree and has lower node degrees for all eight modules.