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Schematic display of epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) in pancreatic cancer development. Circulating epithelial, circulating mesenchymal and circulating epithelial/mesenchymal cells are displayed to show the heterogeneity of circulating tumor cells (CTCs) (A). (B) shows the concept of early dissemination before malignancy. Mechanisms involved in this process are widely unknown and part of current research.
