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Distribution of gene-associated CpGs that were differentially methylated in gonadotroph nonfunctioning pituitary adenomas (NFPAs) and normal pituitary. (A) Volcano plots of differentially methylated CpG sites. (B) Differences in the proportions of aberrantly methylated CpGs, stratified according to gene position (5’ promoter including TSS1500, TSS200, 5’UTR, and first exon and gene body/3’ UTR), as well as CpG content (CpG island, open sea, and shelf/shore).
