Table 1.
Dual effects of lncRNAs in various stage of BC progression.
| Function | LncRNA | Ensembl ID | Subcellular Localization | Signaling Axis and Pathway | References | |
|---|---|---|---|---|---|---|
| Promote | invasion and migration of BC cells | DANCR | ENSG00000226950 | Cytoplasm | DANCR/EZH2/ABCG2 | [27] |
| DANCR/miRNA-216a-5p | [30] | |||||
| H19 | ENSG00000130600 | Cytoplasm | H19/miR-152/DNMT | [36] | ||
| HOTAIR | ENSG00000228630 | Cytoplasm and nucleus | HOTAIR/P53/AKT/JNK/MMPs | [44] | ||
| HOTAIR/AKT/mTOR | [45] | |||||
| HOTAIR/miR-20a-5p/HMGA2 | [46] | |||||
| LINC00152 | ENSG00000222041 | Cytoplasm | LINC00152/BRCA1/PTEN | [48] | ||
| LINC00461 | ENSG00000245526 | Nucleus | LINC00461/miR-30a-5p/integrin β3 | [53] | ||
| NEAT1 | ENSG00000245532 | Nucleus | NEAT1/miR-448/ZEB1 | [58] | ||
| LINC01857 | ENSG00000224137 | Nucleus | LINC01857/CREBBP/H3K27Ac and CREB1 | [60] | ||
| distant metastasis of BC cells | H19 | ENSG00000130600 | Cytoplasm | H19/let-7b/CYTH3/ARF | [63] | |
| HOTAIR | ENSG00000228630 | Cytoplasm and nucleus | TGF-β1/CDK5/HOTAIR/H3K27 | [69] | ||
| HIF1A-AS2 | ENSG00000258667 | Cytoplasm | unclear | [180] | ||
| RP1 | ENST00000420172 | Cytoplasm | KLF5/RP1/p27kip1 | [76] | ||
| MALAT1 | ENSG00000251562 | Nucleus | MALAT1/miR-1/slug | [80] | ||
| MALAT1/miR-129-5p | [85] | |||||
| stemness of BC cells | TUNAR | ENSG00000250366 | Cytoplasm | TUNAR/SOX2 | [134] | |
| LINC00511 | ENSG00000227036 | Cytoplasm | LINC00511/miR-185-3p/E2F1/Nanog | [139] | ||
| lncRNA-Hh | lncRNA-Hh/GAS1/SOX2/OCT4 | [136] | ||||
| FEZF1-AS1 | ENSG00000230316 | Nucleus | FEZF1-AS1/miR-30a/Nanog | [138] | ||
| FGF13-AS1 | ENSG00000226031 | Nucleus | FGF13-AS1/IGF2BPs/Myc | [140] | ||
| ES1 | ENSG00000226673 | Nucleus | ES1/Oct4/Sox2/miR-302 | [135] | ||
| RP1 | ENST00000420172 | Cytoplasm | RP1/p-4E-BP1/eIF4E/p27kip1/Snail1 | [76] | ||
| H19 | ENSG00000130600 | Cytoplasm | H19/let-7/HIF-1/PDK1 | [143] | ||
| HOTAIR | ENSG00000228630 | Cytoplasm and nucleus | HOTAIR/miR-34a/SOX2 | [137] | ||
| BC angiogenesis | MALAT1 | ENSG00000251562 | Nucleus | MALAT1/miR-145/VEGF | [148] | |
| Inhibit | invasion and migration of BC cells | GAS5 | ENSG00000234741 | Cytoplasm and nucleus | GAS5/miR-21/RISC | [88] |
| GAS5/miR-196a-5p/FOXO1/PI3K/AKT | [89] | |||||
| MT1JP | ENSG00000255986 | Cytoplasm | MT1JP/miR-24-3p/Wnt/β-catenin | [161] | ||
| NKILA | ENSG00000278709 | Cytoplasm | NKILA/NF-ĸB/MMPs | [100] | ||
| NEF | NEF/miRNA-155 | [97] | ||||
| LET | unclear | [101] | ||||
| TFAP2A-AS1 | TFAP2A-AS1/miR-933/SMAD2 | [102] | ||||
| LncKLHDC7B | unclear | [103] | ||||
| distant metastasis of BC cells | MALAT1 | ENSG00000251562 | Nucleus | PTEN/microRNA/MALAT1 | [109] | |
| MALAT1/YAP-TEAD | [107] | |||||
| MEG3 | ENSG00000214548 | Nucleus | miR-506/SP3/SP1/DNMT1/MEG3 | [111] | ||
| NLIPMT | Cytoplasm | NLIPMT/GSK3β and EMT proteins | [115] | |||
| XIST | ENSG00000229807 | Nucleus | XIST/MSN/c-Met | [125] | ||
| XIST/miR-155/CDX1 | [123] | |||||
| stemness of BC cells | XIST | ENSG00000229807 | Nucleus | XIST/MSN/EMT proteins | [125] | |
| BC angiogenesis | MEG3 | ENSG00000214548 | Nucleus | MEG3/AKT signaling | [150] | |