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. 2019 Nov 8;11(11):1762. doi: 10.3390/cancers11111762

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Up-regulation of claudin-1 mediates cell viability suppressed by DOCK1 deletion in claudin-low breast cells. (A) The knockdown of claudin-1 attenuates the shDOCK1-inhibited cell viability. Claudin-low breast cancer cells were treated with shDOCK1 and/or shCLDN1 for three days. Cells were harvested to measure protein expression and cell viability. The results are expressed as the mean ± SE from three independent experiments. ** p < 0.01, compared with the control group. Cell viability (B) and protein expression (C) were assessed at 48 h after transfection with the human claudin-1-expressed plasmid (hClaudin-1) or the control vector (Vec).