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The Nrf2-targeted genes MTHFD2 is upregulated in lung cancer tissue from patients who went through additional radiation therapy, while there are nine Nrf2-targeted genes which are downregulated in the case of additional radiation therapy: ADH1A, ALDH3A1, ALDH3A2, ADH1B, GPX2, ADH1C, ALDH6A1, AKR1C3, and NQO1. The p-value was calculated with the help of the Mann–Whitney statistical test.
