Table 3.

List of Nrf2-targeted genes and their function. The list was constructed with the help of the Gene String online tool (https://string-db.org/) [166].

Name	Biological Function
ADH1B	Belongs to the zinc-containing alcohol dehydrogenase family.
NQO1	The enzyme is apparently involved in detoxification pathways, as well as in the biosynthetic vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
AKR1C3	Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2, and phenanthrenequinone (PQ) and the oxidation of 9-alpha, 11-beta-PGF2 to PGD2. Preferentially transforms androstenedione (4-dione) to testosterone.
GPX2	Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. tert-Butyl hydroperoxide, cumene hydroperoxide, and linoleic acid hydroperoxide can act as acceptors.
ALDH3A1	Plays a major role in the detoxification of alcohol-derived acetaldehyde. Involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
ADH1C	Alcohol dehydrogenase.
ALDH6A1	Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA; aldehyde dehydrogenases.