Table 1.
Patient demographics and clinical characteristics.
| Variable | All Patients N = 479 No. (%) |
Primary AS N = 169 No. (%) |
Secondary AS N = 259 No. (%) |
Unknown AS N = 51 No. (%) |
p-value |
|---|---|---|---|---|---|
| Age | <0.011,2 | ||||
| Median age (range) | 70 (2–98) | 66 (2–96) | 74 (38–98) | 62 (15–83) | |
| Gender | <0.01 | ||||
| Male | 167 (34.9) | 74 (43.8) | 62 (23.9) | 31 (61.8) | |
| Female | 312 (65.1) | 95 (56.2) | 197 (76.1) | 20 (39.2) | |
| Time since radiation therapy | |||||
| Median time (years, range) | 8 (1–19) | - | 8 (1–19) | - | - |
| Tumor size | 0.601 | ||||
| ≤ 5 cm | 43 (9.0) | 14 (8.3) | 25 (9.7) | 4 (7.8) | |
| > 5 cm | 26 (5.4) | 7 (4.1) | 14 (5.4) | 5 (9.8) | |
| Unknown | 410 (85.6) | 148 (87.6) | 220 (84.9) | 42 (82.4) | |
| Tumor depth | <0.01 | ||||
| Superficial | 134 (28.0) | 21 (12.4) | 112 (43.2) | 1 (2.0) | |
| Deep | 25 (5.2) | 16 (9.5) | 3 (1.2) | 6 (11.8) | |
| Unknown | 320 (66.8) | 132 (78.1) | 144 (55.6) | 44 (86.3) | |
| Distant metastasis | <0.01 | ||||
| No | 324 (67.6) | 106 (62.7) | 201 (77.6) | 17 (33.3) | |
| Yes | 79 (16.5) | 37 (21.9) | 19 (7.3) | 23 (45.1) | |
| Unknown | 76 (15.9) | 26 (15.4) | 39 (15.1) | 11 (21.6) | |
| Surgery | <0.01 | ||||
| Yes | 306 (63.9) | 107 (63.3) | 192 (74.1) | 7 (13.7) | |
| No | 173 (36.1) | 62 (36.7) | 67 (25.9) | 44 (86.3) | |
| Residual disease | 0.273 | ||||
| R0 | 12 (2.5) | 4 (3.7) | 7 (3.6) | 1 (14.3) | |
| R1 | 4 (0.8) | 0 (0.0) | 4 (2.1) | 0 (0.0) | |
| Unknown | 463 (96.7) | 103 (96.3) | 181 (94.3) | 6 (85.7) | |
| Radiation therapy | 0.217 | ||||
| Neoadjuvant | 3 (0.6) | 0 (0.0) | 2 (0.8) | 1 (2.0) | |
| Adjuvant | 49 (10.2) | 20 (11.8) | 27 (10.4) | 2 (3.9) | |
| Neoadjuvant + adjuvant | 2 (0.4) | 0 (0.0) | 2 (0.8) | 0 (0.0) | |
| Primary | 41 (8.6) | 9 (5.3) | 26 (10.0) | 6 (11.8) | |
| No | 384 (80.2) | 140 (82.8) | 202 (78.0) | 42 (82.4) | |
| Chemotherapy | <0.01 | ||||
| Neoadjuvant | 5 (1.0) | 2 (1.2) | 3 (1.2) | 0 (0.0) | |
| Adjuvant | 7 (1.5) | 6 (3.6) | 1 (0.4) | 0 (0.0) | |
| Primary | 47 (9.8) | 13 (7.7) | 22 (8.5) | 12 (23.5) | |
| No | 420 (87.7) | 148 (87.6) | 233 (90.0) | 39 (76.5) |
1 primary vs secondary AS, 2 unknown vs secondary AS.