Table 4.

Multivariable survival analysis.

Variable		Overall Survival
	No. (%)	Hazard Ratio (95% CI)	p-value
Age			<0.012
<65 years	167 (35)	Ref.
≥65 years	312 (65)	1.89 (1.52 – 2.36)
Gender			0.022
Female	312 (65)	Ref.
Male	167 (35)	1.31 (1.05 – 1.64)
Clinical subtype
Secondary AS1	259 (54)	Ref.
Primary AS	169 (35)	1.51 (1.20 – 1.89)	<0.012
Unknown	51 (11)	1.04 (0.71 – 1.52)	0.84
Tumor depth
Superficial	134 (28)	Ref.
Deep	25 (5)	1.93 (1.18 – 3.16)	<0.012
Unknown	320 (67)	1.15 (0.89 – 1.48)	0.29
Distant metastases
No	324 (68)	Ref.
Yes	79 (17)	2.09 (1.54 – 2.85)	<0.012
Unknown	76 (16)	1.72 (1.31 – 2.25)	<0.012
Surgery			<0.012
Yes	306 (64)	Ref.
No	173 (36)	2.52 (1.93 – 3.29)
Radiation therapy			0.10
(Neo)adjuvant	54 (11)	Ref.
Primary	41 (9)	0.91 (0.55 – 1.51)
No	384 (80)	1.26 (0.89 – 1.78)

CI = confidence interval, ¹ RT, UV and Stewart Treves AS, ² p < 0.05.