Table 3.
Statistical power of the susceptible alleles considered separately for study populations.
| SNP | Gene | Effect Allele | Power for Hungarian General Population (N = 1394) * | Power for Roma Population (N = 1008) * |
|---|---|---|---|---|
| rs7903146 | TCF7L2 | T | 12.79% | 9.92% |
| rs10811661 | CDKN2A/B | T | 5.71% | 5.45% |
| rs10946398 | CDKAL1 | C | 5.63% | 5.40% |
| rs1111875 | HHEX | C | 5.27% | 5.19% |
| rs5219 | KCNJ11 | T | 7.92% | 7.00% |
| rs11671664 | GIPR | A | 5.16% | 5.09% |
| rs780094 | GCKR | C | 5.37% | 5.23% |
| rs1387153 | MTNR1B | T | 6.54% | 6.23% |
| rs340874 | PROX1 | C | 5.37% | 5.25% |
| rs10830963 | MTNR1B | C | 6.77% | 6.37% |
| rs2191349 | DGKB–TMEM195 | T | 5.26% | 5.19% |
| rs174550 | FADS1 | T | 5.10% | 5.07% |
| rs10885122 | ADRA2A | G | 5.06% | 5.04% |
| rs11071657 | C2CD4B | A | 5.06% | 5.05% |
| rs7034200 | GLIS3 | A | 5.07% | 5.05% |
| rs560887 | G6PC2 | T | 5.03% | 5.03% |
* The power calculations using the software package Quanto 1.2.4 were based on the average effect sizes obtained from meta-analyses, assuming an alpha-level of 0.05 and a given sample size. In the estimation, we applied the allele frequencies for CEU (Utah Residents (CEPH) with Northern and Western Ancestry) and for GIH (Gujarati Indian from Houston, Texas) populations from the 1000 genome project, phase 3 considering that the Roma population of Europe had arrived to the Western Balkans from north India and then migrated to Europe.