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. 2019 Oct 24;10(11):839. doi: 10.3390/genes10110839

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Deleted genes analyzed in this study and in comparative species used for the phylogenetic analysis. Blue squares represent patients with NF1 microdeletions: patient 1, patient 2, patient 3, and patient 4, respectively. Brown squares represent ingroup species: Homo sapiens, Pan troglodytes, Pongo abelii, Gorilla gorila gorila, Nomascus leucogenys, Macaca mulatta, Callithri Jacchus e Tarsius syrichata, respectively. Green squares represent outgroup species: Canis lúpus familiaris, Bos taurus, Mus musculus e Rattus norvegicus, respectively. Deleted genes in each species are represented with dark circles. Asterisk indicates that the Tarsius syrichata RNF135 gene, and Canis lupus LRRC37B are absent because their sequences are mostly incomplete.