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. 2019 Oct 27;11(11):1667. doi: 10.3390/cancers11111667

Figure 2.

Figure 2

Replication efficacy of the CVV in cholangiocarcinoma (CCA) cell lines and tumors. The WT or CVV (0.1 multiplicity of infection (MOI)) was used to infect HuCCT1 and SNU1196 cells. After 24, 48, and 72 h of infection, cells were harvested. Virus titration was performed using U2OS cells. (a) Replication efficacy of the WT and CVV in HuCCT1 cells. Experiments were done in duplicate. (b) Replication efficacy of the WT and CVV in SNU1196 cells. Experiments were done in duplicate. (c) The bio-distribution of the WT and CVV in HT29-xenograft nude mice confirms the tumor selectivity of the CVV (compared to the WT) in this in vivo model (n = 3).