Skip to main content
. 2019 Nov 5;11(11):1727. doi: 10.3390/cancers11111727

Figure 1.

Figure 1

Schematic overview of GAS6/AXL expression in normal immunological cells including natural killer (NK) cells, dendritic cells (DC), regulatory T cells (Treg), and macrophages (MΦ). GAS6/AXL interaction regulates normal NK cell development, maturation and cytolytic activity. Binding of GAS6 to AXL increases the immunosuppressive capacity of DC and Treg. In macrophages, GAS6/AXL signaling induces autophagy, decreases inflammation, and regulates apoptotic cell clearance. Gas6 = growth arrest-specific protein 6.