Figure 1.

Evaluation of vestibular signs after surgery in the arsanilic acid (unilateral labyrinthectomy with arsanilic acid) and vehicle groups (unilateral labyrinthectomy with phosphate buffer). (A) Changes in weight after surgery. (B) Scores for circling. (C) Scores for muscle dystonia. (D) Scores for landing in the tail-hanging and landing test. (E) Scores for axial rotation in the tail-hanging and landing test. (F) Scores for symptom reactivation after the tail-hanging and landing test. (G) Total scores for the tail-hanging and landing test. (H) Measurement of the angle of head deviation. (I) Angle of head deviation after surgery. (J) Typical nystagmus at 30 h after surgery. (K) Frequency of nystagmus after surgery. In the arsanilic acid group, significant weight loss is seen at 2–3 days after surgery, with gradual recovery by 5 days (A). In the open field, vestibular signs are strongest at 2 days after surgery, followed by gradual recovery to normal by 7 days (B,C). In the tail-hanging and landing test, the arsanilic acid group shows maximum scores at 2 days after surgery, with return to normal by 7 days (D–G). The angle of head deviation is the smallest at 2 days after surgery, with gradual but not complete recovery by 7 days (I). Nystagmus appears at 24 h after surgery and disappears by 48 h (K). * p < 0.05, ** p < 0.01, paired t-test (vs. the previous time point of observation).