Skowron 2011.

Methods	Design: cluster‐RT Groups: intervention group (pharmaceutical care for hypertension); control group (standard care)
Participants	Pharmacies: 55 (28 intervention; 27 control) Pharmacy worker: 95 pharmacists (44 intervention; 51 control) ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐ Pharmacy user: 193 patients with hypertension (70 intervention; 123 control) mean age: 42.9% aged 46 to 60 years, 39.3% aged 61 to 75 years Setting: urban, Krakow Country: Poland
Interventions	Pharmacy worker‐directed intervention: training on detection, classification and monitoring of drug‐related problems, pathophysiology of hypertension, risk factors and life‐style factors influencing the disease, and rules of pharmacotherapy of hypertension Delivered by: researchers (pharmacists) and physicians (specialists in arterial hypertension and cardiology) Type: education meetings Mode of delivery: group TDF: knowledge Duration: 3 x 5‐hour training sessions Length of follow‐up: end of project Pharmacy worker control: wait list; received the same training as the intervention group after final study visit ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐ Pharmacy user‐directed intervention: patients received pharmaceutical care and were educated about pathophysiology, risk factors, treatment and style of life with hypertension, as well as blood pressure measurement, and self‐measurement of blood pressure. Delivered by: pharmacist Type: self‐management; behaviour change; education; medication management Mode of delivery: individual face‐to‐face TDF: knowledge Duration: 12 meetings from November 2004 to January 2006 Length of follow‐up: post intervention (12 months) Pharmacy user control: usual treatment
Outcomes	Pharmacy worker: Uptake: not reported, but of original 55 pharmacies and 95 pharmacists randomised only 39 pharmacies and 74 pharmacists were retained in study Behavioural: not assessed ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐ Pharmacy user: Clinical: SBP/DBP Psychological health: not assessed Behavioural: not assessed Quality of life: SF‐36 Process: knowledge about hypertension (not validated) Costs/HCU: not assessed
Notes	Study/intervention name: none given Funding source: no specific grant
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "Randomization of community pharmacies to control and study group was done by generation of random numbers by computer software."
Allocation concealment (selection bias)	Low risk	Quote: "Randomization of community pharmacies to control and study group was done by generation of random numbers by computer software."
Baseline outcome measures similar	Unclear risk	Differences in baseline for education, age and place of residence. Unclear if this was accounted for in the analysis.
Baseline characteristics similar	High risk	Differences in education, age and residence
Incomplete outcome data (attrition bias) All outcomes	High risk	Significant number of dropouts from both groups
Blinding of outcome assessment (detection bias) All outcomes	High risk	No information on blinding
Protection against contamination	Low risk	Randomisation by pharmacies
Selective reporting (reporting bias)	High risk	No numerical reporting of quality of life
Other bias	High risk	High number of control pharmacies withdrew
Blinding of participants and personnel (performance bias) All outcomes	High risk	No information about blinding provided