Tsuyuki 2016 ‐ RxEACH.

Methods	Design: RT Groups: intervention (CV risk assessment and education); control (usual care)
Participants	Pharmacies: 56 Pharmacy worker: 723 (370 intervention; 353 control) ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐ Pharmacy user: high risk for CVD 723 mean age: intervention 61 ± 12 years; control 62 ± 12 years % female: intervention 43%; control 42% Setting: unclear Country: Alberta, Canada
Interventions	Pharmacy worker‐directed intervention: online modules on case finding, CVD and risk factors, communicating risk, lifestyle behaviours Delivered: online materials as well as access to experts on CVD Type: condition management Mode of delivery: online training and face to face TDF: knowledge, social support Duration: unclear Pharmacy worker control: it appears all pharmacists had training and saw both intervention and control patients. ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐ Pharmacy user‐directed intervention: medication therapy management assessment, and education including lifestyle Delivered by: pharmacists Type: condition management Mode of delivery: face‐to‐face TDF: knowledge Duration: seen every 3 to 4 weeks for 3 months Length of follow‐up: 3 months (end of intervention) Pharmacy user control: usual care with no specific intervention
Outcomes	Pharmacy worker: not assessed ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐ Pharmacy user: Clinical: cardiovascular risk, BP, LDL‐C, HbA1c Psychological health: not assessed Behavioural: smoking cessation Quality of life: not assessed Process: not assessed Costs: not assessed
Notes	Study/intervention name: Alberta Vascular Risk Reduction Community Pharmacy Project (RxEACH) Funding source: Alberta Health, Merck Canada funds for educational materials Al Hamarneh 2017 and Al Hamarneh 2018 (cited under Tsuyuki 2016 ‐ RxEACH) also refer to this study.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Central randomisation
Allocation concealment (selection bias)	Low risk	Central randomisation
Baseline outcome measures similar	Low risk	Similar
Baseline characteristics similar	Low risk	Similar
Incomplete outcome data (attrition bias) All outcomes	Low risk	Accounted for in analysis
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Objective outcome
Protection against contamination	High risk	Pharmacists delivered both intervention and control
Selective reporting (reporting bias)	Low risk	Not apparent
Other bias	Low risk	None detected
Blinding of participants and personnel (performance bias) All outcomes	High risk	Pharmacists not blinded