Table 2.

Molecular signatures of early-onset breast cancer.

Molecular Signatures Groups	Most Common Genetic Alterations
Genomic alterations	SEPP1, ESR1, IL1RN, SCD, TIAM1, UBE2C, CCNB2, CEP55, TOP2A, BIRC5, TPX2, SHCBP1, KIAA0101, PTTG1, UBE2T, DEPDC1, NUSAP1, CCNB1, HELLS, KIF4A, RRM2, IGF1R, APOBEC3A/B, amplification of 11q13 (CCND1), 17q12 (ERBB2), Chr1p34, and copy number loss at Chr15q13
Inflammatory biomarkers	TNF-308G>A polymorphism
miRNA	miR-1228, miR-3196, miR-1275 miR-1207, miR-92b, miR-139, miR-183, miR-182 and miR-96, miR-320, miR-10a, miR-130, miR-127-3p, miR-143, miR-10b, miR-125b, and miR-195
Signaling pathways	RANK/RANKL