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. 2019 Nov 1;10(11):882. doi: 10.3390/genes10110882

Figure 1.

Figure 1

Domain map of the full-length BRCA1 protein (1863 amino acids), emphasizing its middle exon-11-derived region (light blue; bulged if included in Δ11q, but not Δ11 isoforms), which contains two nuclear localization signals (NLS), a coiled-coil domain (CCD), eight serine/threonine phosphorylation spots (pinned S or T on an encircled P), and binding positions for proteins (yellow area, black bars) and for damaged DNA. For comparison, indicated to the left and right of exon 11, are additional protein binding positions (yellow area, grey bars), a position of binding to DNA ends, further serine phosphorylation spots (smaller) and the following domains: RING (which binds, e.g., BARD1), NES (nuclear export signal), BRCT phosphopeptide recognition domains, and a CCD that mediates interaction with PALB2, which bridges to BRCA2. Below, in boxes, are the parts contained in smaller isoforms (connected by broken lines for skipped parts), with the intron-11-derived C-tail of BRCA1-IRIS (bottom) indicated by a small yellow/orange box (not present in full-length BRCA1 or other isoforms).