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. 2019 Nov 1;11(11):1701. doi: 10.3390/cancers11111701

Figure 7.

Figure 7

Binding to the interferon lambda box1-box2 peptide does not affect JAK1 or JAK1 V658F kinetic parameters. (A), Summary of ATP KM values from kinase activity assays in the presence and absence of 2 µM IFNλR peptide. IFNλR binding did not result in a significantly different ATP KM for JAK1. (B), Summary of kcat values from kinase activity assays in the presence and absence of 2 µM IFNλR peptide. IFNλR binding did not result in a significantly different ATP kcat for JAK1. Error bars represent standard error of the mean from three independent experiments (n = 3).