Table 2.
Sensitivity of ovarian cancer cells to verteporfin and NLC-verteporfin.
| Cell Lines | Culture Conditions | Verteporfin IC50 (nmol·L−1) |
NLC-Verteporfin IC50 (nmol·L−1) |
|
|---|---|---|---|---|
| SKOV3 | 2D | 2 h | 17.8 ± 0.9 | 7.3 ± 0.4 |
| 24 h | 23.8 ± 0.9 | 8.8 ± 0.5 | ||
| 3D | 2 h | 41.2 ± 4.2 | 29.3 ± 7.1 | |
| 24 h | 9.3 ± 0.7 | 9.7 ± 1.1 | ||
| OVCAR3 | 2D | 2 h # | 117.5 ± 14.4 | 116.4 ± 22.7 |
| 24 h | 94.9 ± 15.4 | 97.5 ± 17.4 | ||
| 3D | 2 h | 28.9 ± 0.8 | 36.6 ± 3.2 | |
| 24 h | 9.7 ± 1.0 | 5.3 ± 0.5 | ||
The drug concentrations required to inhibit cell growth by 50% (IC50) at 2 h or 24 h in SKOV3 or OVCAR3 cells cultured in monolayer (2D) or spheroids (3D) and after light exposure (690 nm; 10 J·cm-2). Data represent the mean ± SD (SKOV3, n = 3; OVCAR3, n = 4, except # n = 2). Each independent experiment was performed in triplicate.