Table 2.

Clinical characteristics, pathological findings, and treatment in familial non-medullary thyroid cancer (FNMTC) affected members from Families 1, 2 and 3.

Kindred	K1	K1	K1	K1	K1	K2	K2	K2	K2	K3	K3
Patient	Patient II.2	Patient II.3	Patient II.4	Patient II.5	Patient III.1	Patient II.1	Patient II.2	Patient III.1	Patient III.2	Patient II.1	Patient II.2
Index Case	No	Yes	No	No	No	No	Yes	No	No	No	Yes
Age at Diagnosis	53	57	51	50	36	41	37	30	24	35	34
Presentation	Toxic MNG	MNG	MNG	Toxic MNG	Nodule on US screening	Thyroid nodule	Thyroid nodule	Thyroid nodule	Nodule on US screening	Thyroid nodule	Thyroid nodule
Histology	PTC	PTC	PTC	PTC	PTC	PTC	PTC	PTC	PTC	Hüthle cell carcinoma	PTC
Multicentricity	No	No	Yes	No	Yes	No	No	No	Yes	No	Yes
Bilateralism	No	No	Yes	No	Yes	No	No	No	No	No	No
Local Invasion	No	Yes	Yes	No	Yes	No	Yes	No	No	No	Yes
Stage 1 (TNM)	T1N0M0	T1N0M0	T2N0M0	T1NOMO	T1aN1bMO	T1N0M0	T2N0M0	T2N0M0	T2N0M0	T2N0M0	T1N1M0
Surgery	TT + LN dissection	TT + LN dissection	TT + LN dissection	TT + LN dissection	TT + LN dissection	TT + LN dissection	TT + LN dissection	TT + LN dissection	TT + LN dissection	TT + LN dissection	TT + LN dissection
Radioiodine Ablation (mCu)	Yes (311)	Yes (199)	Yes (118)	Yes (113)	Yes (28)	Yes (100)	Yes (300)	Yes (100)	Yes (100)	Yes (unknown)	Yes (unknown)
Radiotherapy	No	No	No	No	No	No	No	No	No	No	No
Disease Status 2	NED	NED	NED	NED	NED	NED	NED	NED	NED.	NED	NED

US, Ultrasound. PTC, Papillary-thyroid cancer. TT, Total thyroidectomy. LN, lymph node; NED, No Evidence of Disease. MNG, Multinodular Goiter. ¹ Staging was based on the tumor–node–metastasis (TNM) classification of the American Joint Committee on Cancer 2016. ² Disease status was assessed based on follow-up cervical ultrasonography, radioiodine scanning, and the stimulated serum thyroglobulin level.