Table 1.
Published datasets used for meta-analysis. Microarray and RNA-SEQ datasets including tissue of origin were classified as being derived from either “primary epithelia”, “cell line—cancer”, “cell line—non-cancer”, “other mammalian” or “other non-mammalian”, for subsequent analyses.
| Gene | Species | Dataset | Tissue/Cell Line | Classification/Origin | Reference |
| grh | Drosophila melanogaster | 1 | 2–3 hour whole embryos | Other - non-mammalian | Nevil et al., Genetics, 2017 |
| 2 | 11–12 hour whole embryos | Other - non-mammalian | Nevil et al., Genetics, 2017 | ||
| 3 | 15–16 hour whole embryos | Other - non-mammalian | Nevil et al., Genetics, 2017 | ||
| 4 | 13–16 hour whole embryos | Other - non-mammalian | Yao et al., Development, 2017 | ||
| 5 | 13–16 hour whole embryos | Other - non-mammalian | Yao et al., Development, 2017 | ||
| 6 | Stage 16–17 whole embryos | Other - non-mammalian | Yao et al., Development, 2017 | ||
| Grhl | Neurospora crassa | 7 | 48 hour aerial hyphae and conidia | Other - non-mammalian | Pare et al., PLoS ONE, 2012 |
| Grhl2 | Mus musculus | 8 | E9.5 Non-neural ectoderm | Primary Epithelia | Ray et al., Development,2016 |
| 9 | E16.5 Lung epithelium | Primary Epithelia | Kersbergen et al., Dev. Biol., 2018 | ||
| 10 | E16.5 Lung epithelium | Primary Epithelia | Kersbergen et al., Dev. Biol., 2018 | ||
| 11 | E9.5 Cranial tissue | Other - mammalian | Pyrgaki et al., Dev. Biol., 2011 | ||
| 12 | Extraembryonic trophectoderm-derived tissues at E7.5 | Other - mammalian | Walentin et al., Development, 2015 | ||
| 13 | E9.5 Placenta | Other - mammalian | Walentin et al., Development, 2015 | ||
| 14 | E9.5 First pharyngeal arch (PA1) | Other - mammalian | Carpinelli et al., submitted, 2019 | ||
| 15 | Immortalised Mouse Lung Epithelial Cells (MLE15) | Cell line - Non-Cancer | Varma et al., J. Biol. Chem., 2012 | ||
| 16 | NIH3T3 fibroblast cells | Cell line - Non-Cancer | Werner et al., J. Biol. Chem., 2013 | ||
| 17 | IMCD-3 (inner medullary collecting duct) cell line | Cell line - Non-Cancer | Aue et al., J AmSoc Nephrol, 2015 | ||
| Grhl2 | Canis familiaris | 18 | Madin-Darby Canine Kidney (MDCK) cells | Cell line - Non-Cancer | Pifer et al., Mol. Biol. Cell, 2016 |
| 19 | Madin-Darby Canine Kidney (MDCK) cells | Cell line - Non-Cancer | Pifer et al., Mol. Biol. Cell, 2016 | ||
| Grhl2 | Homo Sapiens | 20 | "Early Passage" Primary Normal Human Epidermal Keratinocytes (NHEK) | Primary Epithelia | Chen et al., Cell Death Dis., 2012 |
| 21 | "Late passage" NHEK | Primary Epithelia | Chen et al., Cell Death Dis., 2012 | ||
| 22 | Undifferentiated primary human bronchial epithelial cells | Primary Epithelia | Gao et al., PNAS, 2014 | ||
| 23 | 4T1 breast tumour cells | Cell line - Cancer | Xiang et al., PLOS ONE, 2012 | ||
| 24 | HMLE-Twist-ER cells | Cell line - Cancer | Cieply et al., Cancer Res., 2012 | ||
| 25 | MSP (mesenchymal sub-population) cells obtained from HMLE cells | Cell line - Cancer | Farris et al., Mol Cancer Res. 2016 | ||
| 26 | OVCA429 (ovarian cystadenocarcinoma; intermediate epithelial [IE] phenotype) | Cell line - Cancer | Chung et al., Scientific Reports, 2016 | ||
| 27 | LNCaP (human prostate carcinoma cells) | Cell line - Cancer | Paltoglou et al., Cancer Res. 2017 | ||
| Gene | Species | Dataset | Tissue/Cell line | Classification/Origin | Reference |
| Grhl3 | Mus musculus | 28 | Embryonic day 18.5 (E18.5) embryo backskin | Primary Epithelia | Yu et al., Dev. Biol., 2006 |
| 29 | E14.5 Bladder | Primary Epithelia | Yu et al., EMBO J, 2009 | ||
| 30 | E16.5 Bladder | Primary Epithelia | Yu et al., EMBO J, 2009 | ||
| 31 | E18.5 Bladder | Primary Epithelia | Yu et al., EMBO J, 2009 | ||
| 32 | E14.5 Skin | Primary Epithelia | Gordon et al., J Clin. Invest., 2014 | ||
| 33 | E16.5 Skin | Primary Epithelia | Gordon et al., J Clin. Invest., 2014 | ||
| 34 | E18.5 Skin | Primary Epithelia | Gordon et al., J Clin. Invest., 2014 | ||
| 35 | Adult Skin | Primary Epithelia | Gordon et al., J Clin. Invest., 2014 | ||
| 36 | Adult Skin | Primary Epithelia | Gordon et al., J Clin. Invest., 2014 | ||
| 37 | Adult Skin | Primary Epithelia | Gordon et al., J Clin. Invest., 2014 | ||
| Grhl3 | Homo sapiens | 38 | NHEK (Neonatal Human Epidermal Keratinocytes) cells | Primary Epithelia | Hopkin et al., PLoS Genet. 2012 |
| 39 | NHEKs and adult psoriasis skin | Primary Epithelia | Gordon et al., J Clin. Invest., 2014 | ||
| Grhl3-Isoform 1 | Homo Sapiens | 40 | Human Embryonic Kidney neuroepithelial cell line (HEK-293) | Cell line - Non-Cancer | Haendeler et al., Arter. Thromb. Vasc. Biol., 2013 |
| Grhl3-Isoform 3 | Homo Sapiens | 41 | HEK-293 | Cell line - Non-Cancer | Haendeler et al., Arter. Thromb. Vasc. Biol., 2013 |