Table 3.
Gene Ontology (GO) analysis of the most differentially regulated cellular processes in all biological contexts, following modulation of grh/Grhl function. Functional Gene Ontology (GO) annotations are over-represented among the 200 genes positively regulated by grh/grhl, with the highest evidence of regulation across all species (highest fold change score aggregated over all the datasets).
| Source | Term Name | Term ID | n of Term Genes | n of Query Genes | n of Common Genes | Corrected p Value |
|---|---|---|---|---|---|---|
| Gene Ontology (Biological Process) | ||||||
| BP | biological adhesion | GO:0022610 | 1351 | 80 | 18 | 1.69 × 10−2 |
| BP | cell adhesion | GO:007155 | 1343 | 80 | 18 | 1.56 × 10−2 |
| BP | cell-cell adhesion | GO:0098609 | 776 | 79 | 14 | 6.29 × 10−3 |
| BP | cell-cell adhesion via plasma membrane adhesion molecules | GO:0098742 | 245 | 79 | 10 | 1.43 × 10−4 |
| BP | calcium-independent cell-cell adhesion via plasma membrane adhesion molecules | GO:0016338 | 23 | 79 | 6 | 9.48 × 10−7 |
| BP | developmental process | GO:0032502 | 6212 | 78 | 45 | 3.91 × 10−3 |
| BP | anatomical structure development | GO:0048856 | 7793 | 78 | 44 | 1.43 × 10−3 |
| BP | tissue development | GO:0009888 | 1926 | 66 | 27 | 6.12 × 10−8 |
| BP | epithelium development | GO:0060429 | 1218 | 77 | 26 | 8.22 × 10−10 |
| BP | epidermis development | GO:0008544 | 459 | 77 | 19 | 2.62 × 10−11 |
| BP | multicellular organismal process | GO:0032501 | 7414 | 74 | 48 | 4.19 × 10−3 |
| BP | multicellular organism development | GO:0007275 | 5321 | 78 | 41 | 3.72 × 10−3 |
| BP | system development | GO:0048731 | 4760 | 78 | 40 | 5.09 × 10−4 |
| BP | animal organ development | GO:0048513 | 3428 | 77 | 35 | 2.65 × 10−5 |
| BP | skin development | GO:0043588 | 412 | 77 | 21 | 1.18 × 10−14 |
| BP | water homeostasis | GO:0030104 | 69 | 77 | 5 | 2.14 × 10−2 |
| BP | epithelial cell differentiation | GO:0030855 | 759 | 77 | 19 | 1.83 × 10−7 |
| BP | epithelial cell differentiation involved in embryonic placenta development | GO:0060671 | 3 | 25 | 2 | 1.39 × 10−2 |
| BP | epidermal cell differentiation | GO:0009913 | 353 | 77 | 16 | 1.13 × 10−9 |
| BP | keratinocyte differentiation | GO:0030216 | 299 | 77 | 16 | 8.72 × 10−11 |
| BP | keratinization | GO:0031424 | 224 | 77 | 15 | 2.25 × 10−11 |
| BP | cornification | GO:0070268 | 111 | 73 | 11 | 8.16 × 10−10 |
| BP | multicellular organismal water homeostasis | GO:0050891 | 64 | 77 | 5 | 1.48 × 10−2 |
| BP | regulation of water loss via skin | GO:0033561 | 22 | 77 | 5 | 5.79 × 10−5 |
| BP | establishment of skin barrier | GO:0061436 | 20 | 77 | 5 | 3.43 × 10−5 |
| BP | epithelial cell morphogenesis | GO:0003382 | 32 | 25 | 3 | 2.65 × 10−2 |
| BP | embryonic placenta morphogenesis | GO:0060669 | 25 | 31 | 3 | 2.17 × 10−2 |
| BP | labyrinthine layer morphogenesis | GO:0060713 | 21 | 31 | 3 | 1.26 × 10−2 |
| BP | branching involved in labyrinthine layer morphogenesis | GO:0060670 | 12 | 31 | 3 | 2.11 × 10−3 |
| BP | epithelial cell morphogenesis involved in placental branching | GO:0060672 | 3 | 25 | 2 | 1.39 × 10−2 |
| BP | peptide cross-linking | GO:0018149 | 59 | 64 | 5 | 3.86 × 10−3 |