Table 4.
Conservation of differentially regulated genes between mouse, Drosophila and human across all biological contexts, following modulation of grh/Grhl function.
| Grhl Targets - Mus Musculus | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Rank | Mus musculus Gene Symbol | Regulation | Average Normalised Score | Significant Differential Regulation in Drosophila | Significant Differential Regulation in in Homo sapiens | ||||||
| Orthologue | Rank | Regulation | Average Normalised Score | Orthologue | Rank | Regulation | Average Normalised Score | ||||
| 1 | Prom2 | Positive | 0.163 | prominin-like | PROM2 | 361 | Positive | 0.0116 | |||
| 2 | Tmem54 | Positive | 0.154 | No known orthologue | TMEM54 | 1062 | Positive | 0.0178 | |||
| 3 | Cldn4 | Positive | 0.116 | No known orthologue | CLDN4 | 28 | Positive | 0.0264 | |||
| 4 | Cldn23 | Positive | 0.106 | No known orthologue | CLDN23 | ||||||
| 5 | Ppl | Positive | 0.0812 | shot | PPL | 110 | Positive | 0.0187 | |||
| 6 | Grhl2 | Positive | 0.0752 | grh | 577 | Positive | 0.0323 | GRHL2 | 159 | Positive | 0.0165 |
| 7 | Rab15 | Positive | 0.0663 | RabX4 | RAB15 | ||||||
| 8 | Ocln | Positive | 0.0655 | Su(Tpl) | OCLN | 1141 | Positive | 0.00717 | |||
| 9 | Gm19601 | Negative | 0.0645 | No known orthologue | POLR2K * | ||||||
| 10 | Tslp | Positive | 0.064 | No known orthologue | TSLP | 1957 | Positive | 0.00534 | |||
| 11 | Gm3579 | Negative | 0.0608 | No known orthologue | No known orthologue | ||||||
| 12 | Cdh1 | Positive | 0.0592 | CadN2 | CDH1 | 138 | Positive | 0.0177 | |||
| 13 | Snx31 | Positive | 0.0568 | CG5734 | SNX31 | ||||||
| 14 | Slc6a19 | Negative | 0.0542 | CG43066 | SLC6A19 | ||||||
| 15 | 2310001H18Rik | Positive | 0.0526 | No known orthologue | No known orthologue | ||||||
| 16 | Il17re | Positive | 0.0522 | No known orthologue | IL17RE | ||||||
| 17 | Evpl | Positive | 0.0514 | shot | EVPL | 2179 | Positive | 0.00501 | |||
| 18 | Gm20305 | Negative | 0.0512 | No known orthologue | No known orthologue | ||||||
| 19 | Lad1 | Positive | 0.0508 | Nuak1 | LAD1 | 412 | Positive | 0.0102 | |||
| 20 | Aldh1a3 | Positive | 0.0503 | CG31075 | ALDH1A3 | 1528 | Positive | 0.00614 | |||
| 21 | Sprr1a | Positive | 0.0494 | CG17377 | SPR1A | ||||||
| 22 | Rbbp8 | Positive | 0.0487 | No known orthologue | RBBP8NL | ||||||
| 23 | Tmprss11b | Positive | 0.0485 | CG11836 | TMPRSS2 | ||||||
| 24 | Sod3 | Negative | 0.0468 | CG5948 | SOD3 | ||||||
| 25 | Cyp2b19 | Negative | 0.0465 | Cyp18a1 | CYP2B6 | ||||||
| 26 | Car6 | Negative | 0.0464 | CAH7 | 582 | Positive | 0.0323 | CA6 | |||
| 27 | Car2 | Positive | 0.0463 | CAH1 | 590 | Positive | 0.0323 | CA2 | |||
| 28 | Fmo2 | Negative | 0.0461 | Fmo-2 | FMO2 | ||||||
| 29 | Defb3 | Positive | 0.0456 | No known orthologue | HBETAD3 | ||||||
| 30 | Rab25 | Positive | 0.0453 | Rab11 | RAB25 | 241 | Positive | 0.0137 | |||
| 31 | Prss8 | Positive | 0.045 | CG16749 | PRSS8 | ||||||
| 32 | Cldn6 | Positive | 0.045 | No known orthologue | CLDN6 | ||||||
| 33 | Gsta2 | Negative | 0.0448 | GstS1 | GSTA1/2/3/5 | ||||||
| 34 | Aox4 | Negative | 0.0446 | ry | AOX1 | ||||||
| 35 | Tmprss13 | Positive | 0.0441 | Sb | TMPRSS13 | 5 | Positive | 0.0346 | |||
| 36 | Smpdl3b | Positive | 0.0437 | CG32052 | SMPDL3B | ||||||
| 37 | Ap1m2 | Positive | 0.0434 | AP-1mu | AP1M2 | 464 | Positive | 0.0105 | |||
| 38 | Pax8 | Negative | 0.0433 | sv | PAX8 | ||||||
| 39 | Klk6 | Positive | 0.0433 | CG12951 | KLK6 | 176 | Positive | 0.0157 | |||
| 40 | Il33 | Positive | 0.0425 | No known orthologue | IL33 | ||||||
| 41 | Fabp5 | Positive | 0.0424 | fabp | FABP5 | ||||||
| 42 | Sfn | Positive | 0.0419 | 14-3-3zeta | SFN | 418 | Positive | 0.0109 | |||
| 43 | Cldn1 | Positive | 0.0417 | No known orthologue | CLDN1 | 442 | Negative | 0.0108 | |||
| 44 | Slpi | Positive | 0.041 | CG5639 | SLPI | ||||||
| 45 | Unc93a | Negative | 0.0409 | CG4928 | 1219 | Negative | 0.041 | UNC93A | |||
| 46 | Krt6b | Positive | 0.0408 | LamC | KRT6B | ||||||
| 47 | Macc1 | Positive | 0.0399 | No known orthologue | MACC1 | ||||||
| 48 | Rptn | Positive | 0.0393 | No known orthologue | RPTN | 79 | Positive | 0.0203 | |||
| 49 | Gsta1 | Negative | 0.039 | No known orthologue | GSTA1 | ||||||
| 50 | 9930013L23Rik | Positive | 0.0387 | No known orthologue | CEMIP | ||||||