Table 5.

The top 50 most differentially regulated genes in primary epithelia following modulation of grh/Grhl function. Orthologues of the genes highlighted in red were screened and validated in subsequent Q-RT-PCR experiments in grhl3^-/- zebrafish.

Rank	Gene	Regulation	Normalised Score
1	Cldn23	POSITIVE	0.0954
2	Ppl	POSITIVE	0.0693
3	Prom2	POSITIVE	0.0689
4	Gm19601	NEGATIVE	0.0689
5	Tslp	POSITIVE	0.0684
6	Gm3579	NEGATIVE	0.065
7	Ocln	POSITIVE	0.0633
8	Slc6a19	NEGATIVE	0.0579
9	2310001H18Rik	POSITIVE	0.0562
10	Gm20305	NEGATIVE	0.0547
11	Aldh1a3	POSITIVE	0.0538
12	Tmprss11bnl	POSITIVE	0.0519
13	Snx31	POSITIVE	0.0517
14	Sod3	NEGATIVE	0.05
15	Cyp2b19	NEGATIVE	0.0496
16	Car6	NEGATIVE	0.0496
17	Cldn4	POSITIVE	0.0494
18	Fmo2	NEGATIVE	0.0493
19	Defb3	POSITIVE	0.0488
20	Gsta2	NEGATIVE	0.0479
21	Aox4	NEGATIVE	0.0476
22	Evpl	POSITIVE	0.047
23	Klk6	POSITIVE	0.0462
24	Il33	POSITIVE	0.0455
25	Cldn1	POSITIVE	0.0446
26	Slpi	POSITIVE	0.106
27	Unc93a	NEGATIVE	0.106
28	Krt6b	POSITIVE	0.105
29	Sprr1a	POSITIVE	0.105
30	Rptn	POSITIVE	0.102
31	Gsta1	NEGATIVE	0.101
32	Cemip	POSITIVE	0.0999
33	Fabp7	POSITIVE	0.0991
34	Adh6a	NEGATIVE	0.0985
35	Wfdc12	POSITIVE	0.0961
36	Fxyd4	POSITIVE	0.096
37	Krt78	NEGATIVE	0.0956
38	Tmem54	POSITIVE	0.0953
39	Gldc	NEGATIVE	0.0951
40	Gdpd1	NEGATIVE	0.0945
41	Slurp1	POSITIVE	0.0939
42	Hyal4	NEGATIVE	0.0934
43	Lce3f	POSITIVE	0.0933
44	Unc93a2	NEGATIVE	0.0932
45	Sptlc3	POSITIVE	0.0926
46	Pglyrp1	NEGATIVE	0.0924
47	Gm10639	NEGATIVE	0.0915
48	Gdpd3	NEGATIVE	0.0912
49	Cldnb8	POSITIVE	0.0912
50	Tmprss4	POSITIVE	0.0894