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. 2019 Oct 31;10(11):870. doi: 10.3390/genes10110870

Figure 3.

Figure 3

Deletions in helicase deficient C.elegans strain gk10 show characteristic deletions throughout their genome that invariable start at the 3′ end of G-rich DNA. (A) Wild type animals. (B) Offspring of gk10 with a “variable abnormal (vab)” notched head phenotype (insert). (C–E) Genetic complementation assays pointed to mutations in the vab-1 gene and PCR studies revealed that the vab phenotype in gk10 animals result from deletions close to exon 5 of the vab-1 gene. Deletions that invariably start at the 3′ end of G-rich DNA were identified throughout the C.elegans genome in ~50% of poly guanine tracts longer than 18 G’s. Numbers represent base pairs.