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. 2019 Aug 3;106(6):1380–1388. doi: 10.1002/cpt.1558

Figure 4.

Figure 4

Arithmetic mean (SE) plots of high‐sensitivity C‐reactive protein (hsCRP; mg/L), interleukin (IL)‐6 (pg/mL), tumor necrosis factor (TNF)‐alpha (pg/mL), and beta‐defensin‐2 (BD‐2, pg/mL) from screening (SCR) until week (WK) 24. Very high value of hsCRP observed in one patient (67.8 mg/L on day 39/week 5) is concomitant to the adverse event of “Pharyngitis streptococcal” (days 38−42). Another patient had relatively high values of hsCRP (9.2, 5, and 31.3 mg/L at week 2, week 3, and week 4, respectively) when he presented a concomitant adverse event of “upper respiratory tract infection” (days 14−24). The high SE for TNF‐α was due to one patient who had abnormal values compared with other patients whose values are very consistent.