Table 1.
Summary statistics of midazolam plasma PK parameter values
| Profile day | Statistic | Cmax (ng/mL) | AUC0–12 h (hour·ng/mL) | AUCinf (hour·ng/mL) | t1/2 (h) | Tmax a (h) | Vz/F (L) | CL/F (L/h) |
|---|---|---|---|---|---|---|---|---|
| Baseline | N | 22 | 22 | 22 | 22 | 22 | 22 | 22 |
| Mean (SD) | 26.2 (9.31) | 77.0 (30.6) | 88.1 (35.4) | 4.72 (1.55) | 0.500 (0.250−1.97) | 444 (243) | 64.9 (22.9) | |
| CV% mean | 35.5 | 39.7 | 40.2 | 32.8 | 60.6 | 54.8 | 35.4 | |
| Day 8 | n | 22 | 22 | 21 | 21 | 22 | 21 | 21 |
| Mean (SD) | 29.3 (12.4) | 74.2 (31.2) | 87.1 (39.7) | 4.82 (1.50) | 0.492 (0.217−3.00) | 440 (159) | 65.2 (19.6) | |
| CV% mean | 42.3 | 42.0 | 45.6 | 31.2 | 109.6 | 36.2 | 30.1 | |
| Day 36 | n | 21 | 21 | 20 | 21 | 21 | 20 | 20 |
| Mean (SD) | 25.5 (11.4) | 70.5 (23.2) | 84.0 (27.8) | 4.82 (1.43) | 0.567 (0.233−2.07) | 436 (158) | 66.9 (25.6) | |
| CV% mean | 44.8 | 33.0 | 33.1 | 29.6 | 70.5 | 36.2 | 38.2 |
AUC0−12 h, 0–12‐hour area under the concentration‐time curve; AUCinf, area under the concentration‐time curve to infinity; CL/F, total clearance; Cmax, peak plasma concentration; CV%, percentage of coefficient of variation; PK, pharmacokinetic; t1/2, terminal half‐life; Tmax, time of maximum plasma concentration; Vz/F, volume of distribution based on the terminal phase.
a
Median and range is given for Tmax.