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. 2019 Aug 23;106(6):1319–1327. doi: 10.1002/cpt.1543

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© 2019 AbbVie Inc. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Simulated American College of Rheumatology (ACR) responses (nonresponder imputation (NRI)) at week 12 for the immediate‐release twice daily (b.i.d.) and extended‐release once daily (q.d.) dosing regimens. Lines and shaded areas represent the median and 90% prediction intervals for the immediate‐release 3, 6, 12, and 18 mg b.i.d. dosing regimens in the BALANCE I (anti‐TNF‐inadequate responders (IRs)) and II methotrexate (MTX‐IRs) studies. Symbols and dashed lines represent the simulated median and 90% prediction intervals for the extended‐release 15 and 30 mg q.d. dosing regimens.