Table 4.
Clinical features of patients receiving AIT on admission or delayed AIT
| Missing data | Patients receiving AIT from day 0 n = 340 | Patients receiving AIT between day > 0 and day 30 n = 226 | p value | |
|---|---|---|---|---|
| Male, n (%) | 0/4 | 227 (68) | 147 (65) | NS |
| Age, years, median [IQR] | 1/1 | 59 [49–73] | 58 [47–70] | NS |
| Clinical presentation on day 0 | ||||
| Delay pain/ICU admission, days, median [IQR] | 0 | 4 [1–11] | 2 [1–5] | < 0.001 |
| Oliguria/anuria, n (%) | 0 | 151 (44) | 99 (44) | NS |
| BISAP score, median [IQR] | 4/14 | 2 [1–2] | 1 [0–2] | < 0.001 |
| Balthazar score grade E, n (%) | 0 | 196 (58) | 155 (69) | < 0.05 |
| Severity criteria on day 0 | ||||
| SOFA score, median [IQR] | 1/11 | 5 [3–7] | 4 [3–6] | < 0.05 |
| Respiratory failure*, n (%) | 0 | 129 (38) | 68 (30) | NS |
| Cardiovascular failure*, n (%) | 0 | 157 (46) | 40 (18) | < 0.001 |
| Renal failure*, n (%) | 0 | 65 (19) | 51 (23) | NS |
| Septic shock, n (%) | 0 | 106 (31) | 4 (2) | < 0.001 |
| Acute respiratory distress syndrome, n (%) | 0 | 36 (11) | 16 (7) | NS |
| Therapeutic management on day 0 | ||||
| Vasoactive support, n (%) | 0/1 | 160 (47) | 42 (19) | < 0.001 |
| Mechanical ventilation, n (%) | 0/4 | 126 (38) | 57 (25) | < 0.01 |
| Fluid loading, n (%) | 1/9 | 270 (82) | 169 (75) | NS |
| Renal replacement therapy, n (%) | 1/7 | 40 (12) | 20 (9) | NS |
| Main treatments between day > 0 and day 30 | ||||
| Need for red blood cells transfusion, n (%) | 0 | 113 (33) | 78 (35) | NS |
| Duration of mechanical ventilation, days, median [IQR] | 2/8 | 3 [0–11] | 9 [0–21] | < 0.001 |
| Vasoactive support, n (%) | 0/1 | 205 (60) | 126 (56) | NS |
| Renal replacement therapy, n (%) | 1/0 | 91 (27) | 85 (38) | < 0.01 |
| Duration of RRT, days, median [IQR] | 5/6 | 5 [2–15] | 10 [3–16] | NS |
| Duration of AIT, days, median [IQR] | 13/11 | 5 [2–12] | 7 [3–14] | < 0.01 |
| Main complications between day > 0 and day 30 | ||||
| Acute respiratory distress syndrome, n (%) | 0/2 | 100 (30) | 101 (45) | < 0.001 |
| Septic shock, n (%) | 16/30 | 123 (40) | 85 (40) | NS |
| Pancreatic necrosis, n (%) | 2/16 | 211 (65) | 174 (78) | < 0.01 |
| Infected necrosis, n (%) | 6/22 | 113 (36) | 83 (38) | NS |
| Gastro-intestinal perforation, n (%) | 9/21 | 28 (9) | 22 (10) | NS |
| Vascular thrombosis, n (%) | 5/20 | 50 (16) | 33 (15) | NS |
| Acute mesenteric ischaemia, n (%) | 7/20 | 35 (11) | 27 (12) | NS |
| Intra-abdominal collection, n (%) | 5/16 | 147 (45) | 89 (40) | NS |
| Abdominal compartment syndrome, n (%) | 4/21 | 30 (9) | 35 (16) | < 0.05 |
| Haemorrhage, n (%) | 6/20 | 46 (14) | 33 (15) | NS |
| Peritonitis, n (%) | 8/22 | 58 (18) | 25 (11) | < 0.05 |
| Cholangitis, n (%) | 7/18 | 41 (13) | 16 (7) | < 0.05 |
| Digestive fistula, n (%) | 8/20 | 21 (7) | 9 (4) | NS |
| Clinical management between day > 0 and day 30 | ||||
| Endoscopic necrosectomy, n (%) | 2/4 | 83 (25) | 64 (29) | NS |
| Surgical necrosectomy, n (%) | 2/4 | 131 (39) | 86 (38) | NS |
| Radiological drainage, n (%) | 2/4 | 72 (21) | 47 (21) | NS |
| Duration of ICU stay, days, median [IQR] | 0 | 8 [3–22] | 17 [7–34] | < 0.001 |
| ICU readmission, n (%) | 0/1 | 27 (8) | 23 (10) | NS |
| Hospital mortality rate, n (%) | 0 | 91 (27) | 50 (22) | NS |
| Time to death, days, median [IQR] | 0 | 8 [1–31] | 17 [5–38] | < 0.05 |
NS non-significant, ERCP endoscopic retrograde cholangiopancreatography
*According to the definition of the SOFA score