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. 2019 Nov 20;21(1):181–190. doi: 10.3892/mmr.2019.10834

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 8. — Efficacy of the polyethyleneimine-functionalized magnetic iron oxide/connective tissue growth factor-siRNA complexes on suppressing collagen I and TIMP-1 expression in activated LX-2 cells. (A) Suppression of collagen I and TIMP-1 mRNA levels was quantified by reverse transcription-quantitative PCR analysis (n=3). *P<0.05 vs. the blank and negative control siRNA groups. (B) Suppression of the protein expression of collagen I and TIMP-1 was evaluated by western blot analysis. (C) Relative protein expression levels of collagen I and TIMP-1 were significantly downregulated when compared with the blank and negative control siRNA groups. *P<0.05 vs. the blank and negative control siRNA groups. siRNA, small interfering RNA; TIMP-1, tissue inhibitor of matrix metalloproteinase-1; NC, negative control.