Table 3.
Comparison of baseline characteristics and maternal outcomes of controlled and uncontrolled hypothyroid patients before conception
| CLINICAL CHARACTERISTICS | TSH PRECONCEPTION | P -value | |
|---|---|---|---|
| Controlled (up to 2.5 mIU/L) N = 170 | Uncontrolled (greater than 2.5 mIU/L) N = 207 | ||
| N (%) | N (%) | ||
| Age (years) | |||
| 18–25 | 15 (3.98) | 16 (4.24) | 0.43a |
| 26–33 | 104 (27.59) | 117 (31.03) | |
| 34–40 | 50 (13.26) | 69 (18.30) | |
| 41–47 | 1 (0.27) | 5 (1.33) | |
| Parity | |||
| Nulliparous | 42 (11.29) | 54 (14.52) | 0.8 |
| Multiparous | 125 (33.60) | 151 (40.59) | |
| Body Mass Index (Kg/m2) | |||
| Underweight (< 18.5) | 7 (2.06) | 6 (1.77) | 0.2 |
| Normal (18.5–24.9) | 45 (13.27) | 54 (15.93) | |
| Overweight (25–29.9) | 56 (16.52) | 60 (17.70) | |
| Obesity class I (30–34.9) | 31 (9.14) | 57 (16.81) | |
| Obesity class II and above (> = 35) | 13 (3.83) | 10 (2.95) | |
| Etiology of Hypothyroidism | |||
| Autoimmune | 163 (43.35) | 199 (52.93) | 0.7 |
| Post treatment$ | 7 (1.86) | 7 (1.86) | |
| Thyroid antibodies | |||
| Positive | 54 (36.99) | 60 (41.10) | 0.7 |
| Negative | 14 (9.59) | 18 (12.33) | |
| COMORBIDITIES | |||
| Diabetes Mellitus | |||
| Yes | 10 (2.65) | 18 (4.77) | 0.3 |
| No | 160 (42.44) | 189 (50.13) | |
| Gestational diabetes mellitus | |||
| Yes | 38 (10.08) | 44 (11.67) | |
| No | 132 (35.01) | 163 (43.24) | 0.8 |
| Hypertension | |||
| Normotensive | 151 (40.05) | 176 (46.68) | |
| Previous Gestational Hypertension/Chronic Hypertension | 19 (5.04) | 31 (8.22) | 0.3 |
| MATERNAL OUTCOMES | |||
| Mode of labor (for live births only) | |||
| Spontaneous | 29 (14.50) | 37 (18.50) | 0.24 |
| Induced | 45 (22.50) | ||
| Augmented | 27 (13.50) | 44 (22.00) | |
| Not applicable due to Caesarean section | 18 (9.00) | ||
| Mode of delivery (for live births only) | |||
| LSCS | 80 (23.19) | 124 (35.94) | 0.012 |
| Instrumental | 7 (2.03) | 6 (1.74) | |
| SVD | 71 (20.58) | 57 (16.52) | |
| Pregnancy outcomes | |||
| Abortion | 12 (3.18) | 15 (3.98) | 0.9a |
| Live Birth (Twins/Triplets) | 157 (41.64) | 187 (49.60) | |
| Ectopic | 0 (0.00) | 1 (0.27) | |
| Termination of Pregnancy | 0 (0.00) | 1 (0.27) | |
| Intrauterine Death/Stillbirth | 1 (0.27) | 3 (0.80) | |
| Gestational Hypertension | |||
| Yes | 13 (7.6) | 21 (10.1) | 0.4 |
| No | 157 (92.4) | 186 (89.9) | |
| Pre-Eclampsia | |||
| Yes | 2 (1.2) | 8 (3.9) | 0.19a |
| No | 168 (98.8) | 199 (96.1) | |
| Postpartum Hemorrhage | |||
| Yes | 56 (32.9) | 95 (45.9) | 0.01 |
| No | 114 (67.1) | 112 (54.1) | |
aFischer’s Exact
$Post medical treatment for Grave’s disease, Post-Radioactive Iodine Ablation and Post-Surgical
LSCS Lower segment Caesarean section. SVD Spontaneous vaginal delivery