Fig. 4.
Gd-EOB-DTPA-enhanced MR images of a 47-year-old man with chronic HBV infection and pathologically proven cirrhosis. Images of un-enhanced phase (a) show a hypointense mass predominantly in segment VI. The mass demonstrates typical arterial phase (b) hyperenhancement (not rim), portal venous phase (c) washout and moderate T2 hyperintensity (e). No targetoid appearance is identified on hepatobiliary phase (d) or diffusion-weighted (f, b = 1200s/mm2) images. Note the peritumoral corona enhancement (b, white arrow heads) pattern in arterial phase due to venous drainage from the tumor. The mass was histopathologically proven to be intrahepatic cholangiocarcinoma with hematoxylin-eosin staining at 200 × magnification (g). Cytokeratin 19 is positive at 200 × magnification with immunohistochemical staining (h). The serum alpha-fetoprotein (4.91 ng/ml) and carcinoembryonic antigen 19–9 (17.44 U/ml) levels were within the normal range