Table II.
RFS/OS | ROC | |||||||
---|---|---|---|---|---|---|---|---|
Datasets | C-index | Brier score | Log rank P-value | AUROC | Sensitivity | Specificity | PPV | NPV |
Training set (GSE62254; n=282) | 0.966/0.871 | 0.0108/0.0255 | 2.00×10−16/2.00×10−16 | 0.924 | 0.896 | 0.929 | 0.911 | 0.918 |
Validation set 1 (TCGA; n=295) | 0.929/0.807 | 0.0272/0.0283 | 7.33×10−15/3.87×10−13 | 0.898 | 0.844 | 0.929 | 0.779 | 0.871 |
Validation set 2 (GSE26253; n=432) | 0.950 | 0.0115 | 2.00×10−16 | 0.881 | 0.853 | 0.914 | 0.873 | 0.899 |
SVM, Support Vector Machine; TCGA, The Cancer Genome Atlas; RFS, recurrence-free survival; OS, overall survival; C-index, Concordance index; ROC, receiver operating characteristic; AUROC, area under the receiver operating characteristic curve; PPV, positive prediction value; NPV, negative prediction value.