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. 2019 Nov 22;21(1):61–68. doi: 10.3892/mmr.2019.10843

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Copyright: © Fu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Effects of KR-12-a6 on the mRNA expression of osteogenic differentiation markers. Human bone marrow mesenchymal stem cells were treated with KR-12-a6 at concentrations of 0, 20, 30 or 40 µg/ml, and the mRNA levels of (A) RUNX2, (B) ALP, (C) COL1A1, (D) BSP, (E) BMP2, (F) OSX, (G) OCN and (H) OPN were determined via reverse transcription-quantitative PCR on days 3, 7 and 14 post-KR-12-a6 treatment. Data are presented as the mean ± SD (n=4). *P<0.05, **P<0.01 vs. KR-12-a6 at 0 µg/ml. ALP, alkaline phosphatase; BMP, bone morphogenic protein; BSP, bone sialoprotein; COL1A1, type 1 collagen α1 chain; OCN, osteocalcin; OPN, osteopontin; OSX, osterix; RUNX2, runt-related transcription factor 2.