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Effect of CMR on the growth cone of DRG cells in response to NGF. Images of growth cone in cultured DRG cells before and after 30 min exposure to NGF are shown. Asterisks indicate the NGF gradient. Scale bar, 50 µm. NGF, nerve growth factor; CMR, Cortex Mori Radicis extract; TRPC1, transient receptor potential canonical channel 1; si-, small interfering RNA; DRG, dorsal root ganglia.
