Table 3.

Selected meta-analyses comparing prostate cancer-specific mortality and overall mortality between radical prostatectomy and radiation therapy.

References	Study description	Results	Notable limitations
Wallis et al. (30)	Meta-analysis of 19 studies of low to moderate risk of bias (Newcastle-Ottawa used for assessment), up to 118,830 pooled patients	Worse OM (aHR = 1.63) and PCM (aHR = 2.08) with RT compared with RP	Residual confounding, limited quality control regarding adequacy of ADT, RT dose in included studies
Roach et al. (29)	Meta-analysis of 14 studies. Stratified studies by use of “reliability score” incorporating comorbidity adjustment, ADT quality, and study size	10-year OM and PCM favored RP over RT, by 10 and 4%, respectively. Higher “reliability” associated with differences of 5.5 and 1%, respectively.	Residual confounding, use of unvalidated “reliability score” based on somewhat subjective criteria to stratify included studies

ADT, androgen deprivation therapy; OM, overall mortality; PCM, prostate cancer-specific mortality; RP, radical prostatectomy; RT, radiation therapy.