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Mutation spectrum of YFV-17D and PLLAV following infection in AG129 mice. (A) Schematic presentation of study design. AG129 mice were inoculated i.p. with either a range of inocula of YFV-17D; 10−2–10−1 PFU, or 104 PFU of YFV-17D (n = 3/group) or with 20 µg of PLLAV (n = 7). Mice brains were harvested and homogenized for plaque purification prior to sequencing. (B) Mutation frequencies in brain-derived YFV-17D and PLLAV following neurotropic infection in AG129 mice.
