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. 2019 Dec 4;8(1):1734–1746. doi: 10.1080/22221751.2019.1694394

Figure 2.

Figure 2.

Mutation patterns observed in YFV-17D infected mice. (A) Graphical presentation of genomes of 73 brain-derived, plaque-purified virus clones of YFV-17D following i.p. inoculation and neuroinvasion in AG129 mice (n = 6). (B) Graphical presentation of 86 similar virus clones following i.p. injection of 20 µg of PLLAV-YFV17D and neuroinvasion in AG129 mice (n = 7). Horizontal blue lines represent individual YFV-17D genomes with blue circles as 5’ and 3’ UTRs, respectively. Red, green and orange diamonds represent missense, silent and mixed mutations, respectively (mixed = parental + mutant nucleotide). For a full list of mutations see Supplementary Tables S4 and S5.