Figure 1.

Sensitized chemotherapy to HNE-1 cells. (A) HNE-1 cells viability after incubated with blank Tf-PAAs, free MTX and Tf-PAAs-MTX for 24 h (37 °C and 5% CO₂, n = 5). (B) Intracellular GSH of HNE-1 cells treated with different formulations (n = 5). (C) HNE-1 cells viability after incubated with Tf-PAAs-MTX and PAAs-MTX (37 °C and 5% CO₂, n = 5). (D) Cytotoxicity of Tf-PAAs-MTX to HNE-1 cells and 3T3 cells (37 °C and 5% CO₂, n = 5).