Table 3.
Diagnostic impacts of methylation profiling
| Category | N | % | |
|---|---|---|---|
| Diagnostic effecte | Change in diagnosis | 13 | 24 |
| Resolution of differential diagnosis | 17 | 31 | |
| Molecular refinement | 16 | 29 | |
| Diagnostic validation | 9 | 16 | |
| WHO grade changee | Upgrade | 10 | 18 |
| Downgrade | 3 | 5 | |
| Assign grade | 2 | 4 | |
| Unchanged | 40 | 73 | |
| All molecular refinementse | Change in IDH mutation status | 9 | 16 |
| Final determination of an unclear IDH mutation status | 23 | 42 | |
| Identification of molecular subtype | 20 | 36 | |
| Determination of 1p/19q co-deletion status | 6 | 11 | |
bn = 47
en = 55