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. 2019 Dec 5;19:1192. doi: 10.1186/s12885-019-6362-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Expression of CCN3 is upregulated in oxaliplatin-resistant HCC. The increased resistance to oxaliplatin was in MHCC97H-OXA and Hep3B-OXA over that of parental cells (a). PCR (b), ELISA (c), Immunoblotting (d) and Immunofluorescence (e) revealed that the expression of CCN3 in MHCC97H-OXA cells was significantly higher than that of parental cells. IHC revealed CCN3 expression was significantly up-regulated in oxaliplatin-resistant HCC subcutaneous tissue (f)