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. 2019 Dec 5;19:1192. doi: 10.1186/s12885-019-6362-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — High expression of CCN3 and α-SMA is the positively associated poor prognosis in HCC. The expression of CCN3 is positively correlated with α-SMA (a, A; a, b, c B). The expression of α-SMA in high CCN3 HCC group was higher than that of α-SMA in low CCN3 HCC group (b, A). The patients with high expression of CCN3/α-SMA had significantly lower OS and higher CRR than the patients with low expression of CCN3 (a, b, C). HCC patients were classified into three subgroups based on CCN3 and α-SMA expression levels, and patients with high expression of CCN3 and α-SMA had the highest CRR and lowest OS (c, C)