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. 2019 Dec 5;19:1192. doi: 10.1186/s12885-019-6362-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — CCN3 induce the remodeling of HSC with elevation of cytokines relating to HCC malignancy. The significantly changed cytokines expression profiles were found in CCN3 treated LX2 by cytokines array (a). RANTES, TGFβ and TIMP-2 were selected for immunoblotting, and NFκB was proved as one of the control signaling pathway (b). The reduced migration and inhibited proliferation of LX2 were proved in the CM from NFκB inhibitor EVP4593 treated MHCC97H (c)