Table 1.

Correlations between CCN3/SMA and clinicopathology feature in 86 patients with HCC

Variable	No. of Patient			No. of Patient
	CCN3high	CCN3low	p	SMA high	SMA low	p
Age, y
≥ 53	14	25	0.419	18	21	0.397
<53	19	28		26	21
Sex
Men	26	44	0.624	36	34	0.918
Women	7	9		8	8
HBsAg
Positive	30	48	0.958*	39	39	0.501*
Negative	3	5		5	3
Cirrhosis
Yes	29	46	0.883*	42	34	0.085*
No	4	7		2	9
Serum, AFP
≥ 20	21	32	0.762	29	24	0.403
<20	12	21		15	18
Serum, ALT
≥ 75	11	27	0.110	15	23	0.053
<75	22	26		29	19
Tumor dimension
≥ 5 cm	9	4	0.013	10	3	0.044*
<5 cm	24	49		34	39
No. of tumors
Multiple	4	2	0.139*	3	3	0.953*
Single	29	51		41	39
Vascular invasion
Yes	9	4	0.023*	7	6	0.834
No	24	49		37	36
Tumor encapsulation
Complete	8	27	0.014	12	23	0.009
None	25	26		32	19

For CCN3, and SMA median values were used as cut-off points for definition of subgroups (low expression and high expression groups)

^*Fisher’s exact tests, and Chi-square tests for all other analyses

Boldface in table indicates the difference has statistical significance (p<0.05)