Table 2.
Continuous renal replacement therapy metrics
| Variables | Flexitrate N = 37 |
tRCA N = 23 |
Heparin N = 20 |
P-Valuea |
|---|---|---|---|---|
| Hours of CRRT Per Session | 70 (27, 90) | 95 (40, 155) | 88 (37, 146) | NS |
| Blood Flow Rate (ml/min) | 150 | 150 | 150 | NS |
| Post-filter Replacement rate (ml/hr) | 741 (600, 1000) | 900 (500, 1280) | 1083 (589, 1443) | NS |
| Dialysate rate (ml/hr) | 1000 (1000, 1500) | 1400 (1000, 1500) | 1500 (1212, 1952) | P < 0.001 |
| PBP rate (ml/hr) | 1496 (1373, 1504) | 142 (118, 167) | 144 (100, 225) | P < 0.001 |
| Fluid removal rate (ml/hr) | 170 ± 92 | 219 ± 107 | 186 ± 63 | NS |
| Total effluent rate (ml/hr) | 3399 ± 599 | 2429 ± 631 | 2781 ± 819 | P < 0.001 |
| CRRT Dose (ml/kg/hr) | 33 ± 6 | 28 ± 7 | 30 ± 8 | P = 0.01 |
| Concurrent treatment with Heparin | 5.4% | 39.1% | N/A | P = 0.002 |
Results presented as Mean ± SD or Median (25th, 75th percentile). tRCA, Traditional Regional Anticoagulation. CRRT, Continuous Renal Replacement Therapy
aP-value calculated using ANOVA, Chi-Square, or Kruskal-Wallis tests as appropriate. No significant differences were found between the tRCA and Heparin protocols in post-hoc analysis