FIGURE 4.

Timeline of the presence of carbapenem-resistant Klebsiella pneumoniae positive patients in the ICU in the period from June 2015 to May 2016. The periods of hospitalization are colored in gray. The other colors identify the sequenced samples based on genomic characterization. The colors green, red, and violet correspond to the three clusters identified based on SNPs distance, are reported sporadic cases in blue. Samples obtained from clinical infections (not surveillance swabs) are indicated by stars. The crosses indicate patients death. Black circles indicate the first positive CRKP rectal swab for each patient, negative at the admission. Black triangles indicate the first positive CRKP rectal swab for patients already CRKP-colonized at the admission time into the hospital. Black diamonds indicated the patients that became positive in other hospital wards.